The -catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression
نویسندگان
چکیده
منابع مشابه
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation.
SRp20 is a member of the highly conserved SR family of splicing regulators. Using a variety of reporter gene constructs, we show that SRp20 regulates alternative splicing of its own mRNA. Overexpression of SRp20 results in a reduction in the level of exon 4-skipped SRp20 transcripts and activates the production of transcripts containing exon 4. These exon 4-included transcripts encode a truncat...
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ژورنال
عنوان ژورنال: RNA
سال: 2008
ISSN: 1355-8382
DOI: 10.1261/rna.1253408